Effects of Ketoisocaproic Acid and Inflammation in Glucose

What are the Effects of Ketoisocaproic Acid and Inflammation on Glucose?

Samara Davis
By Samara Davis
editor

July 19, 2021


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  • Ketoisocaproic acid has been shown to have cytotoxic effects via targeting DNA strands. One of the best documented cytotoxic effects of KCO3 is its ability to induce apoptosis. This apoptosis is caused by reactive oxygen species that are produced via the mitochondrial-mediated pathway. Companies like Shenandoah Biotech have been at the forefront of studying the effects of Ketoisocaproic Acid on glucose.

    Ketoisocaproic Acid Inflammation

    The human body is continuously under attack from external sources such as cancer cells or bacteria, and it can also trigger inflammation on its own. One of the main causes of inflammation is ketoisocaproic acid. This article will help you understand how ketoisocaproic acid and other pro-inflammatory molecules can contribute to glucose intolerance and diabetes.

    Constant Protein Influx in the Body

    In the body, proteins are constantly in flux, with some being created while others are being broken down for energy or used as building blocks to create new proteins. To create proteins, the cells need amino acids. Humans can create 22 amino acids by themselves but must acquire the other 8 from food or other sources. 

    These are called essential amino acids. Amino acids are not stored in the body, so they must be constantly supplied to the cells to ensure that the body doesn’t break down its own muscle tissue for fuel when there is no food available.

    Glucose intolerance is a condition where blood sugar levels rise above 140 at rest or even higher with activity. It is often linked to diabetes mellitus, which is also known as diabetes mellitus Type 2 and can lead to complications such as blindness and kidney failure due to the high blood sugar levels in the body.

    How is Ketoisocaproic Acid Formed?

    Keto Acids can be formed from amino acids in the stomach or fats in the liver. Amino acids are broken down from muscle tissue when there is a shortage of glucose. The amino acids first attach to hemoproteins which are a part of red blood cells. They then move to the liver or other organs. 

    In the liver, the amino acids are broken down into individual molecules, and these molecules are then exported through the beta cells of the pancreas into the bloodstream. These molecules enter into other parts of the body and are used as a source of energy in those parts of the body, reducing overall levels of glucose in the blood.

    Keto Acids can be formed from fats in the liver when there is not enough glucose to meet the demands of the cells. Dietary fat is broken down into triglycerides, which are insoluble in water and do not dissolve in the bloodstream. This forms lipoproteins, which are soluble in water and can travel through the bloodstream to other parts of the body where energy is needed.

    Glucose Intolerance

    Glucose intolerance is caused by different factors, including lifestyle and genes. An article published in “Nature Medicine” found that keto acids were produced when fat was metabolized for energy. This study concluded that diet, exercise, and other lifestyle measures could reduce glucose intolerance.

    The Mayo Clinic lists risk factors for developing glucose intolerance, such as having a family history of diabetes, being obese, getting older, and eating high fat or low in fiber. People with prediabetes are more likely to have high levels of ketoacids in the urine. In this case, changing the diet can help to lower the keto acid levels and reduce the risk of complications such as diabetes mellitus Type 2.

    Read about: Benefits of Extra Virgin Olive Oil Like It Lowers Risks of Type 2 Diabetes!

    Inflammation and Glucose Levels

    Inflammation is a specific immune response to harmful stimuli that involves many complex reactions in the body. These responses include a rise in temperature, an increase in blood flow to the area, and numerous chemical reactions, including many of those involved in the inflammatory response. The inflammatory response can be caused by pathogens, toxins, radiation, and other harmful stimuli.

     Inflammation is generally characterized by pain, redness, heat, and swelling in the area being inflamed. The effects of inflammation on glucose levels are not entirely obvious because it depends on so many things that occur in the body during an inflammatory response that is not completely understood. 

    The effects of inflammation on glucose levels may be positive or negative depending on how much inflammation there is and what type it is. A variety of responses occur in response to tissue damage or infections. A single immune response may have several effects on these glucose levels.

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